Duke got a boost from sophomore Javin DeLaurier, who scored a career-high 13 points.
The Blue Devils (8-0) were atop all 65 ballots in results released Monday.
Florida led by as many as 17 points midway through the second half.
Duke trailed 17-3 after Wake Forest scored on a 43-yard touchdown pass.
Duke trailed by as many as eight points but took control midway through the second half.
Trevon Duval had a season-best 18 points.
Arizona was the only other team to receive a No. 1 nod.
Daniel Jones completed 18 of 26 passes for 177 yards and ran for 91 yards.
The Blue Devils wrap up their quick home stand Monday night against Furman.
The Blue Devils (3-0) lost Marvin Bagley III to an injury midway through the first half.