Joel Berry II scored 28 points, including a critical late-game burst of seven straight.
Amile Jefferson, playing in his final game at Cameron Indoor Stadium, added 14 points
Sirk sat out of the 2016 season after partially tearing his left Achilles tendon during fall practice.
Miami held No. 10 Duke a staggering 32 points below its season average.
Bryant Crawford finished with 21 points, and his layup with about 1:20 to play pulled Wake Forest within 93-92.
Tatum hit three 3-pointers as the shot clock approached 0:00 in the second half, all coming after the Cavaliers pulled within 43-42.
Luke Kennard scored 25 points and No. 18 Duke held on to beat Clemson 64-62 on Saturday.
Grayson Allen scored 25 points.
The biggest college basketball game of the season is set to get underway tonight.
Amile Jefferson added 15 points, freshman Jayson Tatum had 12 and Luke Kennard added 10 to help the Blue Devils