Dennis Smith Jr. scored 31 points to lead N.C. State (14-10, 3-8).
Andrew White III scored the first nine points of overtime for the Orange who won a wild game.
On Monday, police said in a statement that their investigation “reveals no evidence of foul play.”
Abdul-Malik Abu and Maverick Rowan each had 13 points for the Wolfpack.
Shackleford graduated from Kinston High School and played basketball for North Carolina State from 1985 through 1988.
N.C. State and UNC play Notre Dame while Duke hosts Baylor early in the season.
Freshman Dennis Smith Jr. scored a season-high 32 points
Wake Forest used a 9-0 run to build a 10-point lead with 6 minutes left, then held off a frantic comeback by the Wolfpack.
Maverick Rowan scored a season-high 21 points.
Freshman Dennis Smith Jr. had 31 points for N.C. State, which shot 41 percent.